Muedzo wekiriniki watanga kuDemocratic Republic of the Congo (DRC) kuti uongorore kushanda kwemushonga unorwisa utachiona hwetecovirimat (unozivikanwawo seTPOXX) muvakuru nevana vane tsoko.Muedzo uchaongorora kuchengetedzwa kwemushonga uye kugona kwayo kudzikisa zviratidzo zvemonkeypox uye kudzivirira zvakakomba, kusanganisira rufu.Pasi pemubatanidzwa wePALM pakati pehurumende, National Institute of Allergy and Infectious Diseases (NIAID), chikamu cheNational Institutes of Health, neNational Institute for Biomedical Research (INRB) yekuDemocratic Republic of the Congo ndivo vari kutungamira chidzidzo ichi..Masangano anodyidzana anosanganisira US Centers for Disease Control and Prevention (CDC), Antwerp Institute of Tropical Medicine, International Alliance of Health Organisations (ALIMA), neWorld Health Organisation (WHO).
Yakagadzirwa nekambani yemishonga SIGA Technologies, Inc. (New York), TPOXX ndiyo FDA yakatenderwa kurwisa chibhokisi.Mushonga unomisa kupararira kwehutachiona mumuviri, kudzivirira kusunungurwa kwehutachiona hwehutachiona kubva mumasero emuviri.Mushonga uyu unonangana neprotein inowanikwa muhutachiona hwechibhokisi uye hutachiona hwemonkeypox.
"Monkeypox inokonzera mutoro wakakura wehurwere uye rufu pakati pevana nevakuru muDemocratic Republic of the Congo, uye nzira dzekurapa dzakavandudzwa dzinodiwa nokukurumidza," akadaro Mutungamiri weNIAID Anthony S. Fauci, MD.Kubudirira kwekurapa kwemonkeypox.Ndinoda kutenda vatinoshanda navo vesainzi kubva kuDRC neveCongo nekuenderera mberi nekubatana kwavo mukusimudzira iyi yakakosha tsvagiridzo yekiriniki.”
Utachiona hweMonkeypox hwakakonzera zviitiko zvenguva nenguva uye kubuda kubva kuma1970, kunyanya munzvimbo dzesango reCentral neWest Africa.Kubva muna Chivabvu 2022, kupararira kwemonkeypox kwakaramba kuchienderera munzvimbo umo chirwere ichi chisati chapararira, kusanganisira Europe neUnited States, nezviitiko zvakawanda zviri kuitika muvarume vanoita zvepabonde nevarume.Kupararira uku kwakaita kuti World Health Organisation neUS Department of Health and Human Services vataure nguva pfupi yadarika nezvehutano hweveruzhinji.Kubva muna Ndira 1, 2022 kusvika Gumiguru 5, 2022, WHO yakashuma 68,900 kesi dzakasimbiswa uye makumi maviri nevaviri vafa munyika zana nenhanhatu, matunhu nematunhu.
Sekureva kweWorld Health Organisation, nyaya dzakaonekwa sechikamu chechirwere chepasi rose chiri kunyanya kukonzerwa nehutachiona hweClade IIb monkeypox.Clade I inofungidzirwa kukonzera zvirwere zvakanyanya uye kufa kwakanyanya, kunyanya muvana, kupfuura clade IIa uye clade IIb, uye ndiyo honzeri yehutachiona muDemocratic Republic of the Congo.Kubva muna Ndira 1, 2022 kusvika Gunyana 21, 2022, African Centers for Disease Control and Prevention (Africa CDC) yakashuma zviitiko 3,326 zvemonkeypox (165 yakasimbiswa; 3,161 vanofungidzirwa) uye zana nemakumi maviri vakafa.
Vanhu vanogona kubata monkeypox kuburikidza nekubata mhuka dzine hutachiona semakonzo, mhuka dzisiri dzevanhu, kana vanhu.Hutachiona hunogona kutapuriranwa pakati pevanhu kuburikidza nekusangana kwakananga nemaronda eganda, zvinwiwa zvemuviri uye madonhwe emhepo, kusanganisira padhuze nekusangana pabonde, pamwe nekusangana zvisina kunanga nembatya dzakasvibiswa kana zvekupfeka.Monkeypox inogona kukonzera zviratidzo zvefuruwenza uye maronda eganda anorwadza.Zvinetso zvinogona kusanganisira kupera mvura mumuviri, kutapukirwa nebhakitiriya, mabayo, kuzvimba kweuropi, sepsis, hutachiona hwemaziso, uye kufa.
Muedzo uyu uchasanganisira vanhu vakuru vanosvika mazana mana nemakumi mashanu nevana vane chirwere chemonkeypox chakasimbiswa murabhoritari chinorema 3 kg.Vakadzi vane pamuviri vanokodzerawo.Vanozvipira vatori vechikamu vanozopihwa zvisina tsarukano kutora tecovirimat kana placebo capsules nemuromo kaviri zuva nezuva kwemazuva gumi nemana pamuyero unoenderana nehuremu hwemutori wechikamu.Chidzidzo ichi chaive nemapofu maviri, saka vatori vechikamu nevatsvaguri havana kuziva kuti ndiani aizogamuchira tecovirimat kana placebo.
Vese vatori vechikamu vacharamba vari muchipatara kwemazuva gumi nemana kwavachawana rubatsiro rwerutsigiro.Vanachiremba vanoongorora vanozogara vachiongorora mamiriro ekiriniki yevatori vechikamu mukati mekudzidza uye vachakumbira vatori vechikamu kuti vape samples dzeropa, swabs dzehuro, uye maronda eganda kuti aongororwe murabhoritari.Chinangwa chikuru chechidzidzo chacho chaiva chekuenzanisa nguva inorehwa nekuporesa kwezvironda zveganda kune varwere vanobatwa ne tecovirimat versus placebo.Vatsvagiri vanozounganidzawo data pane akati wandei echipiri zvinangwa, kusanganisira kuenzanisa kuti vatori vechikamu vakakurumidza sei kuongororwa kuti havana hutachiona hwemonkeypox muropa ravo, kuomarara kwese uye nguva yehurwere, uye kufa pakati pemapoka.
Vatori vechikamu vakaburitswa muchipatara mushure mekunge maronda ese aputika kana kusvuuka uye vakaongororwa kuti havana hutachiona hwemonkeypox muropa ravo kwemazuva maviri akateedzana.Vachacherechedzwa kwemazuva anokwana makumi maviri nemasere uye vanozokumbirwa kudzoka mumazuva makumi mashanu nesere kuti vazoshanyirwa neongororo yekuwedzera ongororo dzekiriniki nerabhoritari.Komiti yakazvimirira yedata uye kuchengetedzwa kwekuchengetedza ichaongorora kuchengetedzwa kwevatori vechikamu mukati menguva yese yechidzidzo.
Chidzidzo chacho chaitungamirirwa nemukuru-mukuru-muongorori Jean-Jacques Muyembe-Tamfum, Mutungamiri Mukuru weINRB uye Purofesa weMicrobiology, Faculty of Medicine, University of Kinshasa, Gombe, Kinshasa;Placid Mbala, MD, PALM Program Manager, Musoro weINRB Epidemiology Division uye Pathogen Genomics Laboratory.
“Ndinofara kuti tsoko haisisiri chirwere chisingatarisirwi uye kuti munguva pfupi iri kutevera, nekuda kweongororo iyi, tichakwanisa kuratidza kuti kune mushonga unorapa chirwere ichi,” vakadaro Dr. Muyembe-Tamfum.
Kuti uwane rumwe ruzivo, shanya Clinicaltrials.gov uye tsvaga ID NCT05559099.Chirongwa chekuedza chichaenderana nehuwandu hwekunyoresa.Muedzo weTPOXX unotsigirwa neNIAID urikuenderera mberi muUnited States.Kuti uwane ruzivo nezvezviedzo zveUS, shanyira webhusaiti yeAIDS Clinical Trials Group (ACTG) uye tsvaga TPOXX kana kudzidza A5418.
PALM ichidimbu che "Pamoja Tulinde Maisha", mutsara wechiSwahili unoreva "kuponesa hupenyu pamwe chete".NIAID yakatanga mubatanidzwa wePALM wekiriniki wekutsvagisa nebazi rezvehutano reDRC mukupindura kubuda kweEbola muna 2018 kumabvazuva kweDRC.Kudyidzana uku kunoenderera mberi sechirongwa chetsvakiridzo yekiriniki yakawanda inosanganisira NIAID, Dhipatimendi rehutano reDRC, INRB uye INRB vanobatana.Chidzidzo chekutanga chePALM chaive chiyedzo chakasarudzika chekurapa kwakawanda kwechirwere cheEbola virus icho chakatsigira kubvumidzwa kwemutemo kweNIAID-yakagadzirwa mAb114 (Ebanga) uye REGN-EB3 (Inmazeb, yakagadzirwa naRegeneron).
NIAID inoitisa uye inotsigira tsvakiridzo kuNIH, United States, nepasirese kuti vanzwisise zvikonzero zvezvirwere zvinotapukira uye zvinodzivirira zvirwere uye kugadzira nzira dziri nani dzekudzivirira, kuongorora, nekurapa zvirwere izvi.Kuburitswa kwenhau, matsamba enhau, uye zvimwe zvine chekuita neNIAID zviripo pawebhusaiti yeNIAID.
Nezve National Institutes of Health (NIH): The National Institutes of Health (NIH) inzvimbo yekuUnited States yezvekurapa yemasangano makumi maviri nemanomwe uye chikamu cheUS Department of Health and Human Services.Iyo NIH ndiyo yekutanga federal agency inoitisa uye inotsigira yekutanga, yekiriniki, uye yekushandura tsvakiridzo yekurapa, ichiongorora zvikonzero, marapirwo, uye marapirwo ezvirwere zvakajairika uye zvisingawanzo.Kuti uwane rumwe ruzivo nezve NIH nezvirongwa zvayo, shanya www.nih.gov.
Nguva yekutumira: Oct-14-2022
